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Diabetic cardiomyopathy (DCM) refers to the presence of abnormal myocardial structure and performance in the absence of other heart-related risk factors (such as coronary artery-related disease, hypertension, and severe valvular disease)

Peripheral but not central administration of GLP-1 fails to inhibit angiotensin (ANG) II-induced drinking in rats that have been treated with monosodium glutamate (MSG) to induce damage of the ARC and the sensory circumventricular organs, suggesting that peripherally administered GLP-1 effects drinking behavior via CNS-dependent mechanisms [760]

Patients aged 75 Years Old or Older The reduced cardiovascular and renal morbimortality associated with the use of GLP-1 RAs is beneficial for this particularly risky population [68,69,70,71,72,73]

Tell your healthcare provider if you become pregnant while using Zepbound

Conflict of interest BG reports receiving fees for serving on an advisory board from Novo Nordisk, AstraZeneca, and MSD

One such study by McClean and colleagues [61] observed that liraglutide can cross the blood-brain barrier in substantial amounts and can prevent deficits in the water maze task performance and object recognition in AD model mice