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# MACE included myocardial infarction, stroke, and death

This approach can help minimize the risk of potential rebound effects or worsening of symptoms associated with stopping the medication abruptly

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Relative exposure in terms of AUC and Cmax for each medication when given with semaglutide compared to without semaglutide

What if I've only lost 5% at six months on semaglutide

For patients whose symptoms significantly impact quality of life, healthcare providers may consider evidence-based pharmacologic options such as certain SSRIs/SNRIs, gabapentin, oxybutynin, or fezolinetant (FDA-approved for moderate to severe vasomotor symptoms)