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One of the four is a GLP-1R / GIPR / GCGR triple agonist (SP-2297, preclinical)

But losing food joy can feel like losing a friend, even if its technically healthy. An indistinct relationship with food is consistently observed in long-term GLP-1 users

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However, patients who need weight management and are motivated to quit smoking may benefit from combining semaglutide with evidence-based cessation strategies like counseling, nicotine replacement therapy, or prescription cessation medications