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Aside from weight gain, the menopause transition is associated with changes in body composition including an increase in fat mass, a decrease in lean mass, and an increase in abdominal adiposity, say researchers

Randomly assigned groups received one of three doses 3 mg, 12 mg, 36 mg or a placebo once a day for 40 weeks

A 2023 study found a 20% cardiovascular risk reduction for obese individuals taking semaglutide compared to those not taking a GLP-1 drug

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doi: 10.17925/EE.2022.18.1.10 [DOI] [PMC free article] [PubMed] [Google Scholar] 45.Fras J.P., Tirzepatide: a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) dual agonist in development for the treatment of type 2 diabetes

'But if they stop the semaglutide and start gaining weight, their bioavailable testosterone will certainly go down.' However, if you continue to lose weight, build muscle, and reduce fat, your testosterone should remain in a healthy range, Dr Gittens says