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DPP-IV inhibitor (DPP4, Merck/millipore) was added to the blood samples immediately after collection and stored at 80 C

Therefore, we believe that the discovery of low-cost oral GLP-1RA analogues or synergists and the continuous elucidation of the possible mechanism of action of GLP-1 are of great significance for the expansion of the field of disease treatment

Clinical trials demonstrate that incremental dose escalationstarting low and advancing every 4-6 weeksmaximizes efficacy while minimizing tolerability issues

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