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doi: 10.1016/S2213-8587(18)30303-6

Especially of interest are the new findings in Parkinsons disease

Under the action of unhealthy metabolic factors (obesity, diabetes), ER stress is initiated, and IRE-1 is activated, which in turn leads to the phosphorylation of IRS1 at the serine 307 residue by activating JNK, thereby impairing insulin signaling

This safety overview is not exhaustive and does not replace full prescribing information

The reason may be that patients is far more likely to have atrial arrhythmias or other common disorders in this subgroup (EF 65%) [76]