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In two head-to-head comparisons, a small, transient mean increase in HR from baseline was observed with lixisenatide
Understanding GLP-1 and Its Role in the Body GLP-1 is a hormone naturally produced in the gut
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In subgroup analysis, lower AF risk was seen in GLP-1RA versus DPP4i users who achieved weight loss, which suggests weight loss as a potential modifier of response to GLP-1RAs.
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GLP-1 RAs have been linked to bowel obstruction, particularly in those with prior GI motility problems
