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Table 14

Oral GLP-1 Formulations and Novel Delivery Systems: With the successful formulation and commercialization of oral semaglutide (Rybelsus), there is now a way to remove barriers to injecting doses of the GLP-1 therapy and thus achieve a more widespread adoption among patients

Analogue formation: Specific amino acid substitutions are made to increase potency and duration of action, creating GLP-1 receptor agonists

Non-Surgical Approach: For those looking for a less invasive option, GLP-1 therapy provides a way to achieve results without undergoing a surgical procedure

Importantly, despite a minimal impact on body weight and hepatic steatosis, LepAB treatment alone had a profound impact on liver fibrosis, as evidenced by a trichrome stain and hepatic expression of fibrosis markers