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Description
Fatty liver disease affects millions of Americans, but emerging research suggests GLP-1 medications like semaglutide may help reduce hepatic fat content and improve liver function through weight loss and metabolic changes

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Although canonically GLP1Rs signal through the stimulatory alpha Gs protein, we find that semaglutide utilizes both Gs- and Gq-signaling pathways in GLP1Rs in the area postrema (AP)the primary site of semaglutide action in the brainto differentially regulate neuronal activation across distinct neuronal clusters

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