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PubMed, Wessel, Jennifer, et al

The reduction in the BMI for those receiving tirzepatide and other incretin-based therapies is substantial but is not instantaneous

In the EU, Mounjaro is also approved for use in weight management and weight loss 2

Co-agonism showed, on murine models, the capability to improve insulin secretion and sensitivity in a weight-dependent and weight-independent manner, probably through its action on nutrient metabolism ( 1.5 Other possible pleiotropic effects of Tirzepatide Pleiotropic effects of GIP receptor stimulation in other tissues, mediated by mechanisms other than typical protein G-coupled receptor pathways, might bring additional benefits

While these are less frequent, theyre important to keep in mind

A secondary mechanistic analysis of the SUMMIT trial found associations between tirzepatide treatment and reductions in circulatory volume and markers of cardiac injury [85]