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3,5 Whereas injectable semaglutide achieved 15% mean weight loss at 68 weeks in the Semaglutide Treatment Effect in People with obesity (STEP-1) study, it requires subcutaneous administration

One of the most effective treatments for obesity is bariatric surgery, which can lead to more weight loss and can even improve conditions like type 2 diabetes better than other methods

In addition, brainstem and hypothalamic GLP-1R activation, which are well established locations of pain modulation, could further contribute to the analgesic effects of these therapies [87]
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