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10.1371/journal.pone.0045167 [DOI] [PMC free article] [PubMed] [Google Scholar] Xu, J

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As a result, cravings increase , satiety drops and your ability to manage weight becomes harder , even going into the next day

Variability in GLP-1R expression across brain regions, metabolic status, sex, CNS penetrance, and biased agonism among different agents further complicates the interpretation of therapeutic effects

The exact reason isnt fully understood, but the dose-dependent pattern across multiple medications suggests it may be related to how these drugs interact with nerve signaling at higher concentrations

[DOI] [PubMed] [Google Scholar] 85.Kohjima M., Higuchi N., Kato M., Kotoh K., Yoshimoto T., Fujino T., Yada M., Yada R., Harada N., Enjoji M., et al
