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We think that the differences compared with our findings exceed the mere facts of using antibodies from different commercial brands or different sample numbers and could possibly arise through methodological differences in the immunohistochemical evaluations

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For neurological CNS biology research, note that Semaglutide has limited blood-brain barrier penetration relative to smaller CNS-active peptides , intracerebroventricular administration routes may be required for studies examining direct central GLP-1R biology independently of peripheral-to-central signalling mechanisms

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