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Nausea, diarrhea, vomiting, constipation, and dyspepsia are documented in clinical trials, with higher doses generally associated with increased frequency and severity of these symptoms

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

Tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

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Smaller, more frequent meals maintain more consistent blood sugar levels and prevent the extreme hunger that can follow a long gap between meals