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For safety outcomes, by R software (version 4.3.2) and the meta package, proportional meta-analyses were carried out, once more utilizing a random effects model and evaluating heterogeneity using the I 2 statistic

Blomberg and collaborators have detailed the incorporation of a -turn mimetic, encompassing both 10- and 7-membered rings, to replace the initial four residues of leu-enkephalin