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This has been demonstrated in human peripheral blood mononuclear cells, where exenatide blocked NF-kB binding to DNA and downregulated both TNF and IL-1 beta expression

In that study, the highest dose group reported an average weight loss of 28.7% at 68 weeks

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Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice

Postgrad Med J 96(1133):156161 Singh K, Aulakh SK, Nijjar GS, Singh S, Sandhu APS, Luthra S, et al (2024) Rebalancing the gut: glucagon-like peptide-1 agonists as a strategy for obesity and metabolic health