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Throughout phylogenetic history, serotonin plays vital roles in the metabolism of various organisms including unicellular organisms, plants, and animals [8]

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Although glycogen synthesis and intracellular glycogen levels proportionally inhibit AMPK activity [86], the increase in glycogen seen in patients receiving GLP-1 agonists may be partially due to GLP-1R/AMPK activation that overrides basal glycogen inhibition of AMPK

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