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This effect is likely mediated by synergistic interactions between the endogenous cannabinoid system and the endogenous opioid system at both the spinal cord and central nervous system levels [66]
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doi: 10.1371/journal.pone.0261986 Cao H, Liu Y, Tian Z, et al
Glucagon-like peptide 1 belongs to a family of hormones called incretins because they enhance insulin secretion due to factors derived from the gut
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