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Together, this multifactorial dilemma stipulates the necessity for the field to investigate novel pharmaceuticals and to extend the therapeutic utility of well-researched drugs already used in clinical practice

Neuroimaging sub-studies provided additional mechanistic insights: functional MRI (fMRI) revealed a reduction in alcohol cue reactivity in the ventral striatum and septal area among patients receiving exenatide, while single-photon-emission computed tomography (SPECT) imaging showed decreased DAT availability in the striatum, caudate, and putamen

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Popular treatments approved by the FDA include Sales for Lillys GLP-1 treatments reached $40 billion in 2025, accounting for 62% of the companys annual revenue