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The novel incretin agonist, named I-M-150847, promotes robust glucose-stimulated insulin exocytosis in cultured pancreatic beta cells

The use of GLP-1 medications has become a cultural health norm, with more than 12% of Americans having been prescribed them or currently taking them

Chronic diseases such as obesity and diabetes, cardiovascular and inflammatory bowel diseases (IBD) share common features in their pathology

GLP-1 prescriptions have surged 587%

In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are peptide-derived analogs that were initially investigated to treat type 2 diabetes