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From $299per dose Shape360 Semaglutide + B12 (0.25mg1.0mg) Semaglutide with vitamin B12 tested active, escalating-dose starter protocol
SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
Discontinuation of treatment (37%) was the most common reason for censoring (Supplementary Table 20)
Dose-dependent hypoglycemia risk exists, particularly when combined with insulin or sulfonylureas
Step 2: Complete an Online Visit Share your weight loss goals and medical history
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