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This review summarizes current evidence on the nutritional implications of GLP1-based pharmacotherapy in adults with obesity, including common gastrointestinal adverse events, reduced energy intake, potential macro and micronutrient inadequacies, and risks of lean mass loss

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Current evidence is limited, but healthcare providers can assess individual risk-benefit profiles

Eating less often means consuming less protein, which can affect lean muscle maintenance

These findings highlight the potential of high-potency GLP-1 agents as effective monotherapy options in managing obesity and glycemic control in adolescents.