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Jens Juul Holst, Professor of Medical Physiology at the University of Copenhagen, joins host Areesha Moiz to discuss the discovery and development of GLP-1-based therapies
This was supported by another study in which liraglutide attenuated the TNF or high-glucose-mediated induction of PAI-1, ICAM-1, and VCAM-1 expression in human vascular endothelial cells, the proposed molecular mechanism underlying this effect may involve the regulation of NUR77 expression [61], which is a nuclear receptor and transcription factor involved in regulating gene expression related to cell growth, apoptosis, metabolism, and inflammation

In this study, transcriptional changes were assessed during trans-differentiation of normal human prostate cells to adenocarcinoma and small cell neuroendocrine prostate cancer (44)

Additionally, for individuals with type 2 diabetes, obesity, and heart failure with preserved ejection fraction, GLP-1 receptor agonists are advised to manage glucose and alleviate heart failure symptoms

Human iNKT cells treated with 3.5 nM liraglutide show increased cAMP within 30 minutes, and 18 nM liraglutide inhibits IFN- and IL-4 secretion upon -galactosylceramide stimulation presented by CD1d-expressing cells (43)
