glp-1 agonist gastroparesis Diabetic New data links GLP-1 agonists

Exp Clin Endocrinol Amp Diabetes (2022) 130:35867

Science Advances

Largest reported liraglutide overdose

Potent GLP-1 agonists exert effects by multiple mechanisms including delayed gastric emptying, increased glucose-dependent insulin secretion, reduced glucagon levels, and reduced food intake by CNS effects to cause appetite suppression

Primatesta P, Poulter NR

Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]