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The concern originates from long-term rodent studies on GLP-1 receptor agonists, where C-cell (parafollicular cell) hyperplasia was observed

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& Yeh, HC

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DAQ: t (24) = 0.21, p = 0.83

These modifications allow Ozempic (semaglutide) to hang around much longer bound to a protein called albumin, and resist being broken down by DPPIV enzymes whose job it is to deactivate GLP-1
