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Major challenges in hydrogel-based delivery systems include difficulties with large-scale production, difficulties in precisely controlling gelation, the risk of immunogenicity, and the possibility of uneven drug distribution and retention within brain tissues

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For 10 days, healthy subjects received semaglutide tablets once daily doses orally with 50 mL or 120 mL of water under fasting conditions with post-dose fasting period of 15, 30, 60 or 120 minutes

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