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One real-world evidence study found that patients receiving GLP-1 receptor agonists had a higher risk of ulcerative colitis compared to those on DPP-4 inhibitors (a different diabetes drug class)

Yes, and theyre worth getting excited about

Travel and schedule disruptions Once-weekly dosing is forgiving of schedule shifts

Vomiting occurs less often (10-15% in early weeks) and usually resolves faster than nausea

The mechanisms behind this are multifactorial and include a reduced basal metabolic rate due to hypothyroidism, fluid retention, and potential changes in appetite regulation and energy expenditure

In breast tissue , it acts as a pure antagonist , blocking estrogenic stimulation and preventing or reversing gynecomastia