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However, it is rapidly degraded by the DPP-4 enzyme, giving it a one-two minute half-life

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Botfield HF, Uldall MS, Westgate CSJ, Mitchell JL, Hagen SM, Gonzalez AM et al (2017) A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus

Reviews of formulation science confirm that newer delivery platforms can meaningfully improve solubility and bioavailability relative to native curcumin, although direct comparative clinical validation across systems including pharmacokinetic sub-studies embedded within metabolic trials remains incomplete (1, 8, 9)
