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Higher doses of retatrutide produced significant weight loss, with Phase 2 trials reporting average reductions of about 24% of body weight after 48 weeks
At the same time, retatrutide helps burn more fat

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EMBO J 31:27142736 Wang MC, ORourke EJ, Ruvkun G (2008) Fat metabolism links germline stem cells and longevity in C

On a broader societal level, the use of GLP-1 medications for weight loss may be reinforcing the negative stigmas around fatness and being overweight that often contribute to the development of eating disorders