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Comparing the proportion of participants with zero heavy drinking days by group and treatment period (Figure 4F) showed that the likelihood of zero heavy drinking days increased significantly from weeks 1 through 4 to 5 through 8 in the semaglutide group ( z score, 2.93

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For example, while luminal or vascular administration of butyrate during an isolated perfused colon study increased GLP-1 and PYY secretion 93 , only vascular administration of acetate induced GLP-1 and PYY secretion, with luminal acetate inducing only GLP-1 secretion 93

Percentage change in body weight was calculated as (follow-up weight baseline weight)/baseline weight

Nausea affects between 25% and 44% of people taking these medications, making it the most common side effect