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The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function

doi: 10.1111/dom.14280 179 LarsenPJ

GLP-1 RAs don't suppress insulin secretion or alter ketone metabolism in the same way, making their safety profile meaningfully different

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