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analyzed cognitive skills and proposed that rhGH therapy could help prevent cognitive decline in individuals with PWS, especially those with mUPD ( Differences between mUPD and del15q have also been documented in relation to psychiatric issues: individuals with del15q exhibit higher levels of aggression compared to those with mUPD (p=0.007) ( In relation to orthopedic issues, a higher incidence of scoliosis has been reported among individuals with PWS who have received rhGH treatment and have a deletion (p=0.011)