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Semaglutide users already experience reduced fluid intake due to appetite suppression, creating a compounding dehydration risk

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Central dopamine and prolactin levels plays a key role in the glucose homeostasis control, and their dysregulation could lead to the pathognomonic central insulin resistance depicted in the ominous octet

This reduction in HbA1c appears to be more prominent even though more than 50% were on a submaximal dose of 7 mg oral semaglutide, likely due to tolerance issues

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