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GLP-1RAs modulate oxidative stress, inflammation, and monoaminergic and mesolimbic circuits in preclinical models, resulting in functional improvements in depression and anxiety, and also reducing drug reward (51, 201, 202)

Create routines around meal prep, sleep, hydration, and stress management

Kaur G, Behl T, Bungau S, et al

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There were countless reports of people who were able to adjust their lifestyle, lose weight, and get off of these medications within a set time frame

Semaglutide and tirzepatide also reduce liver fat, with tirzepatide generally showing greater reductions than semaglutide, but neither approaches the 80%+ reductions seen with retatrutide