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Overlapping binding sites of GLP-1 and Fab 3F52 The -helix of the GLP-1R ECD is a critical part of the GLP-1 binding site as shown previously by x-ray crystallography and it is also the primary binding site of Fab 3F52 as shown in this study 31

USA 84 , 34343438 (1987)

doi: 10.1055/s-0029-1210974 34 VilaGJoergensenJOLLugerAStallaGK

Despite robust clinical evidence, barriers such as high costs, limited access, lack of awareness of approved indications, and practitioner hesitancy continue to impede widespread adoption

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