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Historical Comparison: Previous Obesity Drug Timelines Why retatrutide might be faster: Eli Lilly has recent tirzepatide approval experience and knows FDA expectations for GLP-1-class drugs

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The STEP trials (Semaglutide Treatment Effect in People with Obesity) documented that nausea peaked during the first 48 weeks of treatment and during dose escalation phases, then often subsided as patients adapted

Furthermore, earlier evaluations by NICE and HAS did not incorporate retreatment in their economic models, 26,27 and the Japanese HTA largely followed these international approaches

Benefits beyond weight loss and blood sugar GLP-1 medications are not only about the scale
