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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously

Weight loss generally becomes noticeable within the first month, with peak effects occurring between 60-68 weeks of continuous therapy

The American Diabetes Association has warned that abruptly stopping such medications could cause patients to gain weight again and increase their risk for diabetes and heart conditions, the New York Times reported

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"Lean mass changes during GLP-1 receptor agonist therapy: mechanisms and mitigation strategies." Molecular Metabolism

As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels (91)