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Most clinicians prefer to start metformin first and titrate it to 1000 to 2000 mg daily over 2 to 4 weeks before adding semaglutide

Since the different agonists/compounds, all of which stimulate Gs recruitment to the GIP receptor, have distinct pharmacology, they may affect interaction of the various effector molecules with the GIP receptor differently (39, 42) ( Figure 2 )

Standard weight-loss doses may be too high, causing unnecessary side effects

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YL: Data curation, Validation, Writingoriginal draft