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Activation of GLP-1 receptors has been associated in published research with: glucose-dependent insulin secretion suppression of glucagon release delayed gastric emptying reduced food intake altered central appetite signalling improvements in several metabolic markers Unlike Tirzepatide, Semaglutide does not activate GIP receptors
Higher doses showed some increase in heart rate, which is being carefully evaluated in Phase 3 trials
Cardiologists may consider making an informed clinical decision by using reliable CV risk scores in addition to the judgment of available clinical evidence
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