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[24] found that HFpEF patients exhibited more significant microcirculation involvement compared to those without HFpEF

This means patients who have type 2 diabetes requiring better glycemic control, or patients with obesity (BMI 30 or above, or BMI 27 or above with weight-related comorbidities ) who need weight management assistance

This fragmentation makes it nearly impossible to construct a cross-tissue causal model when each domain interprets the data through its own methodological and conceptual lens

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In trials (DURATION program), once-weekly exenatide 2 mg showed slightly more A1c reduction (~1.5% drop from baseline 8.3%) than Byetta BID (~1.0% drop) with fewer GI side effects after initial weeks ( [6] )

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