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Because tirzepatide already slows gastric emptying, taking too much anti-diarrheal medication can lead to severe constipation or even a bowel obstruction

doi:10.1038/s41591-024-02970-5 PubMed: This substudy demonstrated that retatrutide reduced liver fat by 81-82% at the 8mg and 12mg doses over 24 weeks, providing evidence of retatrutides multi-system metabolic benefits beyond weight loss

Some find 8mg sufficient with fewer side effects

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At Noom we are constructing the right pathway off the medication for those who wish to take it

28 Orforglipron demonstrated over 12% weight loss in a 72-week Phase III study, positioning it as a potent alternative to weekly injections