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Weight loss induced by GLP-1GIPLani was also diminished in DIO Gipr -knockout mice (Fig
Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial

2024;73(Supplement_1) doi: 10.2337/db24-2066-LB

Lastly, severe dehydration can lead to blood pressure abnormalities as well as kidney injury, which can sometimes result in permanent kidney damage if not addressed urgently"

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