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Because this effect is entirely glucose-dependent, insulin secretion decreases as plasma glucose approaches normal levels, providing a significant safety advantage over traditional secretagogues

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doi: 10.1016/j.fct.2021.112235 [DOI] [PubMed] [Google Scholar] 47

Other important safety considerations include risk of hypoglycaemia when combined with insulin or sulfonylureas, potential gallbladder disease, and the need for monitoring in patients with pre-existing diabetic retinopathy

Seven additional Phase 3 trials are expected to complete in 2026