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A 2023 study by Devoto and colleagues explored how food images become so "cravingly salient" in obesity in the first place, and newer work on GLP-1's effects on reward and affect is mapping how these drugs reach those circuits

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Blood monocytes differentiate into several types of macrophages: classically activated types (M1) are pro-inflammatory and anti-fibrogenic, whereas alternatively activated M2 types are anti-inflammatory, pro-fibrogenic, and induce M1 cell apoptosis through IL-10 (Mosser and Edwards, 2008)