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Moreover, considering the CVD continuum where it progresses from risk factors such as diabetes to atherosclerosis and CHD, until it leads to heart failure or death [46], GLP-1 analogues act in different stages of this pathophysiological process (see Fig

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Diabetes Care 17(10):11001109

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Shaking can cause the delicate peptide chains to break apart or denature, which may render the compound ineffective