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However, pharmacological and preclinical data are gathering (Table 2)

GLP-1R Activation in the Brain: Neurotrophic Effects, Neuroprotection, Anti-Inflammation, Neurogenesis, and Synaptic Plasticity As expected with the similar mechanisms of disease progression in the gutbrain axis and the broad expression profile of GLP-1Rs in this region, GLP-1R agonists are able to show neuroprotective and neurotrophic effects in various in vitro and in vivo model systems

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