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According to prescribing information, injection sites include abdomen, thigh, or upper arm, rotated weekly to minimize injection site reactions

Together, you can develop a plan for transitioning off the medication gradually

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But one thing to keep in mind is that losing weight, particularly in a rapid manner, can also lead to muscle and bone loss, says John Batsis, MD, an associate professor of medicine in the department of geriatric medicine at the University of North Carolina in Chapel Hill and an American Board of Obesity Medicine (ABOM) diplomate

In these cases, GLP-1 medications do more than promote weight lossthey help manage the underlying conditions that make obesity more dangerous

It is important to note that the paraventricular hypothalamic nucleus receives afferent input from a variety of nuclei including the arcuate nucleus (Bouret et al., 2004a , 2004b