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The treatment-regimen estimand with knee osteoarthritis pain represents the estimated average treatment effect regardless of adherence to study intervention assuming no treatment benefit should participants need significant actions associated with lack of efficacy

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While these mechanisms can explain the protective effect that GLP-1 RA exposure had on the fracture risk of the exposed patients in our study, it is important to consider the fact that the findings mentioned were from studies primarily conducted on patients prescribed GLP-1 RA who had a diagnosis of T2DM, as this is what the drugs were originally FDA-approved to treat

Your stomach adjusts to the slower emptying

That does not automatically mean the medication failed

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