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Methods Study Identification This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines [21]

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Starting the New Medication Your new treatment plan will often begin at a lower dose, allowing your body to adjust before increasing to the therapeutic level

While metformin has long served as the standard first-line therapy, many clinicians are now reconsidering whether a metformin-first and wait strategy is enough for this higher-risk population

Without any food or water restrictions, it provides maximum convenience, with clinical trials showing an average weight loss of up to 12.4%

Adjust semaglutide dosage based on response and tolerability