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DPP-4 inhibitors are implemented into the treatment algorithms of type 2 diabetes in many national and international guidelines ( The various DPP-4 inhibitors do not form a homogenous class of molecules, and they show different interactions with the active site of the enzyme molecule

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This rise in cravings can disrupt appetite regulation even when a GLP 1 agonist is actively working to reduce hunger

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GLP-1 receptor agonists, liraglutide and lixisenatide, also display neuroprotective properties in MPTP mouse models